Glioblastoma (GBM). GBM is the most Love Baby Yoda in heart shirt and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.
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Mail is still delivered and collected here in the U.K. on Christmas Eve, and I believe the same is true for the U.S. also. Although I know that this is not the That Ball Had A Family Shirt in some countries, Christmas Eve is a normal working day in the U.K. and again I believe that the same is true for the U.S. also (though may people do finish work early on Christmas Eve). The question reminded me of how the mail delivered to my house on two different Christmas Eves illustrated how Christmas is not just a time of goodwill when you receive cards and presents in the post, but also a time when life goes on as usual and you can still receive the most unwelcome and unpleasant items of mail as I did on those two occasions. And here I kid you not, believe me, because twice in my life I have received a court summons on Christmas Eve !
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